Uniqua is the protagonist, or main character, of the series and a unique creature known as a "Uniqua."
Uniqua is voiced by LaShawn Tináh Jefferies throughout the entire series. Her singing voice is provided by Jamia Simone Nash in seasons one through three and by Avion Baker in the fourth season. In live performances after 2009, Jamia Nash provided Uniqua's voice, both speaking and singing.
Uniqua is highly energetic. She is often the character to come up with new ideas for adventures, and if she's not, Uniqua will become a large part of the journey. Compared to Tasha, she displays a more tomboy-like personality. On rare occasions, Uniqua and Tasha will get into disagreements over small things, usually due to different opinions. No matter what, Uniqua will find a way to end the quarrel and have a good laugh with her friend.
At her very core, Uniqua knows what it means to be a true friend and has a heart full of compassion. She has a strong sense of loyalty to her friends and she loves to help others. Uniqua is very optimistic, and she's determined to overcome any obstacle she faces on her adventures. Regardless of what role she plays on her adventures with her friends, she always has a sense of humor.
Uniqua lives in a pink-colored house located in the middle of Tyrone's house and Austin's house. It is unknown what most of her house looks like, but a coat rack and table are seen in various episodes when Uniqua exits and enters her home.
Uniqua's skin is a light pink with randomly placed spots (colored a darker pink) around her body. She has white eyes with black pupils. Her other most noticeable feature is her curled antennae at the top of her head. Her eyebrows are a dark red. She wears dark-gloom pink overalls with light pink spots. She also has two red-pink buttons, one for each strap.